{"collection_id":"htan_hms","collection_name":"HTAN-HMS","cancer_types":"Adenocarcinoma","tumor_locations":"Colon","species":"Human","subjects":16,"supporting_data":null,"description":"We are constructing a multi-dimensional atlas of pre-melanoma focused on understanding genetic and\nepigenetic events that transform melanocytes into invasive tumors. Melanoma is a cancer of\nincreasing prevalence that is curable with minor surgery if detected early but life-threatening when\nit metastasizes. Melanomas metastasize when still small, making early detection essential but\nchallenging. Our atlas will delineate the precise sequence of events leading up to pre-melanoma\nthrough detailed spatial analysis of cell-autonomous events such as oncogene mutation and\nnon-autonomous events such as escape from immune surveillance. The atlas is based on\nhighly-multiplexed tissue imaging and single cell sequencing and focused on samples in which the\nfull sequence of events from atypia to invasive melanoma can be visualized in a single specimen. The\natlas will serve as a publicly accessible resource for research scientists, physicians, and patients\nand improve our ability to (i) highlight lesions likely to progress to cancer, (ii) identify\nhigh-risk patients to inform decisions on surgery, (iii) identify low-risk patients to reduce\nunnecessary procedures, (iv) design improved procedures for routine screening of all individuals,\nand (v) inform treatment options when surgery is insufficient. Complementary studies with similar\ngoals (but not supported by HTAN) are studying later stage melanomas.\nPlease see the\n DICOM converted Slide Microscopy images for the HTAN-HMS collection (https://doi.org/10.5281/zenodo.12666872)\n information page to learn more about the images\nand to\nobtain any supporting metadata for this collection.","patients":16,"studies":16,"series":31,"instances":3897,"size_TB":1.233,"modalities":["PR","SM"],"licenses":[{"license_short_name":"CC BY 4.0","series":31,"size_TB":1.233}]}