{"collection_id":"gtex","collection_name":"GTEx","cancer_types":"Non-diseased","tumor_locations":"Various","species":"Human","subjects":971,"supporting_data":"Clinical, Genomics","description":"The GTExGenotype-Tissue Expression (GTEx) Project (https://commonfund.nih.gov) established a data\nresource and tissue bank to study the relationship between genetic variants and gene expression in\nmultiple human tissues and across individuals. The project included contributions from numerous\ngroups with diverse expertise in biospecimen collection and processing, pathology review, molecular\nanalysis, and data management. The contributors are collectively called the GTEx Consortium.\nGTEx collected a total of 26,468 unique tissue samples from 50+ different tissue types, from 956\nhealthy postmortem donors. The standardized biospecimen collection and analysis practices applied\nduring the study served to minimize preanalytical variability associated with specimen-related\nfactors and their potential impact on analytic endpoints. Each GTEx tissue was divided into two\ntissue blocks, one for histology and one for molecular analysis; both tissue blocks were preserved\nin PAXgene Tissue Fixative (Qiagen) solution for 6 to 24 hours, followed by PAXgene Tissue\nStabilizer (Qiagen) as specified in\nthe project-specific standard operating procedures (https://biospecimens.cancer.gov/resources/sops/library.asp)\n. Tissue blocks were processed and\nembedded in paraffin at the GTEx central repository at the Van Andel Institute (MI) and hematoxylin\nand eosin–stained slides were generated from all GTEx donors. Digitally scanned whole slide images\nof PAXgene-fixed/stabilized, paraffin-embedded tissue sections were created using Aperio Scanscope\nsoftware (Leica Biosystems). The digital images were then reviewed and annotated by one of four\nboard-certified pathologists assigned to the GTEx study. There are a total of 25,503 digital\nhistology images in the GTEx collection.\nPlease see the GTEx (https://doi.org/10.5281/zenodo.11099099) information page to learn more about\nthe images and to obtain any supporting metadata for this collection.","patients":971,"studies":971,"series":25503,"instances":128708,"size_TB":8.555,"modalities":["SM"],"licenses":[{"license_short_name":"CC BY 4.0","series":25503,"size_TB":8.555}]}